MUTAGENS AND INFECTIOUS NUCLEIC ACIDS

Inactivation of Two Arboviruses and Their Associated Infectious Nucleic Acids.

Nucleic Acids

The first isolation of what we now refer to as DNA was accomplished by Johann Friedrich Miescher circa 1870. He reported finding a weakly acidic substance of unknown function in the nuclei of human white blood cells, and named this material "nuclein". A few years later, Miescher separated nuclein into protein and nucleic acid components. In the 1920's nucleic acids were found to be major compon...

Nucleic acids.

In: Dyer A, Hudson HG and Williams PA (eds) Ion Exchange Processes: Advances and Applications, p. 39. Cambridge, UK: The Royal Society of Chemistry. Lehto J and Harjula R (1997) Selective separation of radionuclides from nuclear waste solutions with inorganic ion exchangers, React Funct Polym (in press). Navratil JD (1989) Ion exchange technology in spent fuel reprocessing. Journal of Nuclear S...

Nanotechnology and Nucleic Acids

The peculiarities of two approaches in the nanodesign based on the double-stranded nucleic acid molecules are considered. Main attention is devoted to the formation and properties of nanoconstructions based on the double-stranded DNA molecules and the complexes with chitosan, fixed in the spatial structure of particles of their cholesteric liquidcrystalline dispersions, and cross-linked by arti...

Increased attachment of nucleic acids to eukaryotic and prokaryotic cells induced by chemical and physical carcinogens and mutagens.

Significantly enhanced attachment to Ehrlich ascites and Escherichia coli cells was observed for radioactive DNA and RNA in the presence of chemical mutagens and ultimate carcinogens. In some instances, formation of nucleic acid-protein adducts by these compounds further (or similarly) enhanced the binding. DNA irradiated with ultraviolet light in the presence of a protein bound more efficientl...